Article
Normal p53 status and function despite the development of drug resistance in human breast cancer cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Nov 1995
Wosikowski K, Regis J T, Robey R W, Alvarez M, Buters J T, Gudas J M, Bates S E
Abstract excerpt
Loss of or mutations in p53 protein have been shown to decrease both radio- and chemosensitivity. The present study assessed the p53 gene status, ability to arrest in G1 of the cell cycle, the functionality of the p53 transduction pathway, and apoptosis following treatment with radiation in a ser...
Topics
- Apoptosis
- Base Sequence
- Blotting, Western
- Breast Neoplasms
- DNA Damage
- Drug Resistance, Neoplasm
- Female
- Flow Cytometry
- G1 Phase
- Gene Expression Regulation, Neoplastic
- Humans
- Molecular Sequence Data
- Mutation
- Protein-Tyrosine Kinases
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-bcl-2
- RNA, Messenger
- Signal Transduction