Article
Tumor suppressor genes.
BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Feb 1990
Levine A J
Abstract excerpt
The retinoblastoma sensitivity protein (Rb) and the p53 gene product both appear to function as negative regulators of cell division or abnormal cellular growth in some differentiated cell types. Several types of cancers have been shown to be derived from cells that have extensively mutated both...
Topics
- Amino Acid Sequence
- Animals
- Exons
- Eye Neoplasms
- Humans
- Infant
- Mice
- Molecular Sequence Data
- Mutation
- Neoplasms
- Nuclear Proteins
- Oncogene Proteins
- Phosphoproteins
- Retinoblastoma
- Retinoblastoma Protein
- Sequence Homology, Nucleic Acid
- Suppression, Genetic
- Tumor Suppressor Protein p53