Article
Selective induction of p53 and chemosensitivity in RB-deficient cells by E1A mutants unable to bind the RB-related proteins.
Proceedings of the National Academy of Sciences of the United States of America - 28 Oct 1997
Samuelson A V, Lowe S W
Abstract excerpt
The adenovirus E1A oncoprotein renders primary cells sensitive to the induction of apoptosis by diverse stimuli, including many anticancer agents. E1A-expressing cells accumulate p53 protein, and p53 potentiates drug-induced apoptosis. To determine how E1A promotes chemosensitivity, a series of E...
Topics
- Adenovirus E1A Proteins
- Animals
- Antibiotics, Antineoplastic
- Apoptosis
- Doxorubicin
- Drug Resistance
- Humans
- Mice
- Mutation
- Protein Binding
- Retinoblastoma Protein
- Tumor Suppressor Protein p53