The properties of p53 proteins selected for the loss of suppression of transformation.

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Article

The properties of p53 proteins selected for the loss of suppression of transformation.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Jan 1994

Olson D C, Levine A J

Abstract excerpt

The wild-type p53 protein can act as a suppressor of transformation in that it will block or reduce the formation of adenovirus E1A plus ras mediated transformants of primary rat embryo fibroblasts (C. A. Finlay et al., Cell, 57: 1083-1093, 1989). In those experiments, all of the transformed cell...

Topics

Animals
Base Sequence
Cell Transformation, Viral
Cloning, Molecular
Genes, Tumor Suppressor
Genes, p53
Genes, ras
In Vitro Techniques
Molecular Sequence Data
Mutation
Phenotype
Plasmids
Rats
Transcription, Genetic
Transfection
Tumor Cells, Cultured
Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 8123594

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8123594-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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