Article
Use of genetic suppressor elements to dissect distinct biological effects of separate p53 domains.
Proceedings of the National Academy of Sciences of the United States of America - 17 Sept 1996
Ossovskaya V S, Mazo I A, Chernov M V, Chernova O B, Strezoska Z, Kondratov R, Stark G R, Chumakov P M, Gudkov A V
Abstract excerpt
p53 is a multifunctional tumor suppressor protein involved in the negative control of cell growth. Mutations in p53 cause alterations in cellular phenotype, including immortalization, neoplastic transformation, and resistance to DNA-damaging drugs. To help dissect distinct functions of p53, a set of genetic suppressor elements (GSEs) capable of inducing different p53-related phenotypes in rodent embryo...
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