Article
Use of genetic suppressor elements to dissect distinct biological effects of separate p53 domains.
Proceedings of the National Academy of Sciences of the United States of America - 17 Sept 1996
Ossovskaya V S, Mazo I A, Chernov M V, Chernova O B, Strezoska Z, Kondratov R, Stark G R, Chumakov P M, Gudkov A V
Abstract excerpt
p53 is a multifunctional tumor suppressor protein involved in the negative control of cell growth. Mutations in p53 cause alterations in cellular phenotype, including immortalization, neoplastic transformation, and resistance to DNA-damaging drugs. To help dissect distinct functions of p53, a set...
Topics
- Animals
- Base Sequence
- Cell Survival
- Cells, Cultured
- DNA, Complementary
- DNA-Binding Proteins
- Drug Resistance
- Embryo, Mammalian
- Etoposide
- Fibroblasts
- Genes, p53
- Molecular Sequence Data
- Phenotype
- RNA, Messenger