Article
Clonality and stability of the p53 gene in human astrocytic tumor cells: quantitative analysis of p53 gene mutations by yeast functional assay.
International journal of cancer - 29 Jul 1996
Tada M, Iggo R D, Ishii N, Shinohe Y, Sakuma S, Estreicher A, Sawamura Y, Abe H
Abstract excerpt
Mutation of the p53 gene is found in about one third of astrocytic brain tumors, and expansion of tumor cell clones containing mutant p53 has been implicated in astrocytic tumor progression. However, admixture of normal cells in astrocytic tumor specimens limits the power of traditional studies o...
Topics
- Astrocytoma
- Base Sequence
- Brain Neoplasms
- Cloning, Molecular
- DNA Mutational Analysis
- DNA, Neoplasm
- Genes, p53
- Glioblastoma
- Humans
- Molecular Sequence Data
- Mutation
- Saccharomyces cerevisiae
- Tumor Cells, Cultured