Article
Cells with TP53 mutations in low grade astrocytic tumors evolve clonally to malignancy and are an unfavorable prognostic factor.
Oncogene - 21 Oct 1999
Ishii N, Tada M, Hamou M F, Janzer R C, Meagher-Villemure K, Wiestler O D, Tribolet N, Van Meir E G
Abstract excerpt
It is important to understand how low grade tumors recur and progress to malignant lesions since this dramatically shortens patient survival. Here, we evaluated the concept that malignant progression and poor prognosis of low grade astrocytic tumors are TP53 dependent through clonal expansion of mutated cells. TP53 status was established in primary and recurrent tumors from 36 patients with WHO grade II...
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