Article
Pattern of mutant p53 expression in human astrocytomas suggests the existence of alternate pathways of tumorigenesis.
Cancer - 15 Jan 1994
Chozick B S, Weicker M E, Pezzullo J C, Jackson C L, Finkelstein S D, Ambler M W, Epstein M H, Finch P W
Abstract excerpt
BACKGROUND: Clinical observations suggest that malignant astrocytomas may arise from well-differentiated, low-grade tumors that have undergone anaplastic progression or may develop de novo. Mutations that alter the function of the p53 gene product are thought to play a critical role in astrocytoma tumorigenesis. The authors studied the pattern of mutant p53 expression in astrocytomas to define its role in the...
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