Article
Single cell monitoring of growth arrest and morphological changes induced by transfer of wild-type p53 alleles to glioblastoma cells.
Proceedings of the National Academy of Sciences of the United States of America - 14 Feb 1995
Van Meir E G, Roemer K, Diserens A C, Kikuchi T, Rempel S A, Haas M, Huang H J, Friedmann T, de Tribolet N, Cavenee W K
Abstract excerpt
Mutation of the p53 tumor suppressor gene is one of the earliest identified genetic lesions during malignant progression of human astrocytomas. To assess the functional significance of these mutations, wild-type (WT) p53 genes were introduced into glioblastoma cell lines having mutant, WT, or null endogenous p53 alleles. Populations of cells with mutant or null endogenous p53 alleles and exogenous WT p53 were...
Topics
- Alleles
- Brain Neoplasms
- Cell Division
- Gene Transfer Techniques
- Genes, p53
- Glioblastoma
- Humans
- Transcriptional Activation
- Tumor Cells, Cultured