Article
Functional evaluation of p53 and PTEN gene mutations in gliomas.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Oct 2000
Kato H, Kato S, Kumabe T, Sonoda Y, Yoshimoto T, Kato S, Han S Y, Suzuki T, Shibata H, Kanamaru R, Ishioka C
Abstract excerpt
We screened mutations of two major tumor suppressor genes, p53 and PTEN, in 66 human brain tumors using a yeast-based functional assay and cDNA-based direct sequencing, respectively. The frequency of p53 mutations was 28.8% (19 of 66) and was higher in anaplastic astrocytoma (9 of 14, 64.3%,) than in glioblastoma multiforme (GBM; 7 of 27, 25.9%,), supporting previous speculation that there are at least two...
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