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Article

Multiple developmental roles for CRAC, a cytosolic regulator of adenylyl cyclase.

Developmental biology - 1 Apr 1999

Wang B, Shaulsky G, Kuspa A

Abstract excerpt

Receptor-mediated activation of adenylyl cyclase (ACA) in Dictyostelium requires CRAC protein. Upon translocation to the membrane, this pleckstrin homology (PH) domain protein stimulates ACA and thereby mediates developmental aggregation. CRAC may also have roles later in development since CRAC-null cells can respond to chemotactic signals and participate in developmental aggregation when admixed with wild-type...

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Identifiers

PMID: 10075837
DOI: 10.1006/dbio.1998.9193

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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