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Article

A MAP kinase necessary for receptor-mediated activation of adenylyl cyclase in Dictyostelium.

The Journal of cell biology - 1 Feb 1995

Segall J E, Kuspa A, Shaulsky G, Ecke M, Maeda M, Gaskins C, Firtel R A, Loomis W F

Abstract excerpt

Analysis of a developmental mutant in Dictyostelium discoideum which is unable to initiate morphogenesis has shown that a protein kinase of the MAP kinase/ERK family affects relay of the cAMP chemotactic signal and cell differentiation. Strains in which the locus encoding ERK2 is disrupted respond to a pulse of cAMP by synthesizing cGMP normally but show little synthesis of cAMP. Since mutant cells lacking ERK2...

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Identifiers

PMID: 7844154
DOI: 10.1083/jcb.128.3.405
PMCID: PMC2120359

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Source receipt: pubmed, retrieved 7 Sept 2026.

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A MAP kinase necessary for receptor-mediated activation of adenylyl cyclase in Dictyostelium.PMID 7844154Read ↗

Molecular genetics of signal transduction in Dictyostelium.Semantic proximity Read ↗

Regulation of Dictyostelium early development genes in signal transduction mutants.Semantic proximity Read ↗

Phosphorylation of actin-related protein 2 (Arp2) is required for normal development and cAMP chemotaxis in Dictyostelium.Semantic proximity Read ↗

Protein kinase A regulates the Ras, Rap1 and TORC2 pathways in response to the chemoattractant cAMP in Dictyostelium.Semantic proximity Read ↗

Constitutively active adenylyl cyclase mutant requires neither G proteins nor cytosolic regulators.Semantic proximity Read ↗

Release of Ca2+ from the endoplasmic reticulum contributes to Ca2+ signaling in Dictyostelium discoideum.Semantic proximity Read ↗

An adenylyl cyclase that functions during late development of Dictyostelium.Semantic proximity Read ↗

Constitutively active G protein-coupled receptor mutants block dictyostelium development.Semantic proximity Read ↗

Multiple cyclic AMP receptors are linked to adenylyl cyclase in Dictyostelium.Semantic proximity Read ↗

Direct biochemical measurements of signal relay during Dictyostelium development.Semantic proximity Read ↗

An intersection of the cAMP/PKA and two-component signal transduction systems in Dictyostelium.Semantic proximity Read ↗

A role for cAMP-dependent protein kinase A in early Dictyostelium development.Semantic proximity Read ↗

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