Article
A MAP kinase necessary for receptor-mediated activation of adenylyl cyclase in Dictyostelium.
The Journal of cell biology - 1 Feb 1995
Segall J E, Kuspa A, Shaulsky G, Ecke M, Maeda M, Gaskins C, Firtel R A, Loomis W F
Abstract excerpt
Analysis of a developmental mutant in Dictyostelium discoideum which is unable to initiate morphogenesis has shown that a protein kinase of the MAP kinase/ERK family affects relay of the cAMP chemotactic signal and cell differentiation. Strains in which the locus encoding ERK2 is disrupted respond to a pulse of cAMP by synthesizing cGMP normally but show little synthesis of cAMP. Since mutant cells lacking ERK2...
Topics
- Adenylyl Cyclases
- Amino Acid Sequence
- Animals
- Dictyostelium
- Enzyme Activation
- GTP-Binding Proteins
- Mitogen-Activated Protein Kinase 1
- Molecular Sequence Data
- Mutation
- Phenotype
- Protein Serine-Threonine Kinases