Article
Selection and binding of peptides to human transporters associated with antigen processing and rat cim-a and -b.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 1996
Wang P, Gyllner G, Kvist S
Abstract excerpt
Cytotoxic T lymphocytes recognize antigenic peptides presented by MHC class I molecules. The peptides are generated in the cytosol by proteasomes, and probably also other proteases, and are then translocated into the endoplasmic reticulum (ER) lumen. The transporters associated with Ag processing (TAP) are key molecules for transporting peptides from the cytosol to the lumen of the ER. Using semipermeabilized...
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