Article
Peptide transport in human lymphoblastoid and tumor cells: effect of transporter associated with antigen presentation (TAP) polymorphism.
Immunology letters - 1 Mar 1998
Quadri S A, Singal D P
Abstract excerpt
CD8+ T-cells recognize antigenic peptides presented by major histocompatibility complex (MHC) class I molecules. These peptides bind to MHC class I molecules in the endoplasmic reticulum (ER) lumen. Antigenic peptides are translocated from the cytosol to the lumen of ER by transporter associated...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 2
- ATP Binding Cassette Transporter, Subfamily B, Member 3
- ATP-Binding Cassette Transporters
- Alleles
- Antigen Presentation
- Biological Transport
- Humans
- Interferon-gamma
- Major Histocompatibility Complex
- Peptides
- Polymorphism, Genetic
- Translocation, Genetic
- Tumor Cells, Cultured