Substrate selection by transporters associated with antigen processing occurs during peptide binding to TAP.

doi:10.1016/s0161-5890(98)00059-5

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Article

Substrate selection by transporters associated with antigen processing occurs during peptide binding to TAP.

Molecular immunology - 1 Jun 1998

Gubler B, Daniel S, Armandola E A, Hammer J, Caillat-Zucman S, van Endert P M

Abstract excerpt

Presentation of antigenic peptides by major histocompatibility complex (MHC) class I molecules depends on translocation of cytosolic peptides into the endoplasmic reticulum (ER) by transporters associated with antigen processing (TAP). Peptide transport by TAP is thought to include at least two s...

Topics

Alleles
Amino Acid Sequence
Amino Acid Substitution
Animals
Antigen Presentation
Binding Sites
Carrier Proteins
Humans
Peptides
Protein Binding
Rats
Spodoptera

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