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Article

Substrate selection by transporters associated with antigen processing occurs during peptide binding to TAP.

Molecular immunology - 1 Jun 1998

Gubler B, Daniel S, Armandola E A, Hammer J, Caillat-Zucman S, van Endert P M

Abstract excerpt

Presentation of antigenic peptides by major histocompatibility complex (MHC) class I molecules depends on translocation of cytosolic peptides into the endoplasmic reticulum (ER) by transporters associated with antigen processing (TAP). Peptide transport by TAP is thought to include at least two steps: initial binding of peptide to TAP, and its subsequent translocation requiring ATP hydrolysis. These events can be...

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Identifiers

PMID: 9798647
DOI: 10.1016/s0161-5890(98)00059-5

Genes

TAP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Substrate selection by transporters associated with antigen processing occurs during peptide binding to TAP.PMID 9798647Read ↗

Selection and binding of peptides to human transporters associated with antigen processing and rat cim-a and -b.Semantic proximity Read ↗

A Detailed Analysis of the Murine TAP Transporter Substrate SpecificitySemantic proximity Read ↗

Absence of functional relevance of human transporter associated with antigen processing polymorphism for peptide selection.Semantic proximity Read ↗

Transporter associated with antigen processing preselection of peptides binding to the MHC: a bioinformatic evaluation.Semantic proximity Read ↗

A point mutation in the human transporter associated with antigen processing (TAP2) alters the peptide transport specificity.Semantic proximity Read ↗

Peptide transport in human lymphoblastoid and tumor cells: effect of transporter associated with antigen presentation (TAP) polymorphism.Semantic proximity Read ↗

Principles of peptide selection by the transporter associated with antigen processingSemantic proximity Read ↗

Dependence of peptide binding by MHC class I molecules on their interaction with TAP.Semantic proximity Read ↗

Identifying MHC class I epitopes by predicting the TAP transport efficiency of epitope precursors.Semantic proximity Read ↗

Allele-specific differences in the interaction of MHC class I molecules with transporters associated with antigen processing.Semantic proximity Read ↗

The Transporter Associated With Antigen Processing (TAP): Structural Integrity, Expression, Function, and Its Clinical RelevanceSemantic proximity Read ↗

Allele-dependent processing pathways generate the endogenous human leukocyte antigen (HLA) class I peptide repertoire in transporters associated with antigen processing (TAP)-deficient cells.Semantic proximity Read ↗

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