Dependence of peptide binding by MHC class I molecules on their interaction with TAP.

doi:10.1126/science.270.5233.105

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Article

Dependence of peptide binding by MHC class I molecules on their interaction with TAP.

Science (New York, N.Y.) - 6 Oct 1995

Grandea A G, Androlewicz M J, Athwal R S, Geraghty D E, Spies T

Abstract excerpt

Major histocompatibility complex (MHC) class I molecules bind peptides that are delivered from the cytosol into the endoplasmic reticulum by the MHC-encoded transporter associated with antigen processing (TAP). Peptide capture by immature heterodimers of class I heavy chains and beta 2-microglobu...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 2
ATP Binding Cassette Transporter, Subfamily B, Member 3
ATP-Binding Cassette Transporters
Amino Acid Sequence
Calcium-Binding Proteins
Calnexin
Cell Line
Endoplasmic Reticulum
HLA Antigens
HLA-A1 Antigen
HLA-B Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HLA-B8 Antigen

HLA-G Antigens

Histocompatibility Antigens Class I

Humans

Ligands

Major Histocompatibility Complex

Molecular Sequence Data

Source

Open in PubMed

Identifiers

PMID: 7569935
DOI: 10.1126/science.270.5233.105

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7569935-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Dependence of peptide binding by MHC class I molecules on their interaction with TAP.PMID 7569935Read ↗

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Allele-specific differences in the interaction of MHC class I molecules with transporters associated with antigen processing.Semantic proximity Read ↗

Assembly of tapasin-associated MHC class I in the absence of the transporter associated with antigen processing (TAP).Semantic proximity Read ↗

Recruitment of MHC class I molecules by tapasin into the transporter associated with antigen processing-associated complex is essential for optimal peptide loading.Semantic proximity Read ↗

A Detailed Analysis of the Murine TAP Transporter Substrate SpecificitySemantic proximity Read ↗

The cell biology of major histocompatibility complex class I assembly: towards a molecular understandingSemantic proximity Read ↗

The Transporter Associated With Antigen Processing (TAP): Structural Integrity, Expression, Function, and Its Clinical RelevanceSemantic proximity Read ↗

Substrate selection by transporters associated with antigen processing occurs during peptide binding to TAP.Semantic proximity Read ↗

Critical role for the tapasin-docking site of TAP2 in the functional integrity of the MHC class I-peptide-loading complex.Semantic proximity Read ↗

Distinct functions of tapasin revealed by polymorphism in MHC class I peptide loading.Semantic proximity Read ↗

Identifying MHC class I epitopes by predicting the TAP transport efficiency of epitope precursors.Semantic proximity Read ↗

Quantitative and Qualitative Influences of Tapasin on the Class I Peptide RepertoireSemantic proximity Read ↗

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