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Article

Dependence of peptide binding by MHC class I molecules on their interaction with TAP.

Science (New York, N.Y.) - 6 Oct 1995

Grandea A G, Androlewicz M J, Athwal R S, Geraghty D E, Spies T

Abstract excerpt

Major histocompatibility complex (MHC) class I molecules bind peptides that are delivered from the cytosol into the endoplasmic reticulum by the MHC-encoded transporter associated with antigen processing (TAP). Peptide capture by immature heterodimers of class I heavy chains and beta 2-microglobulin may be facilitated by their physical association with TAP. A genetic defect in a human mutant cell line causes the...

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Source

Identifiers

PMID: 7569935
DOI: 10.1126/science.270.5233.105

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Dependence of peptide binding by MHC class I molecules on their interaction with TAP.PMID 7569935Read ↗

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Recruitment of MHC class I molecules by tapasin into the transporter associated with antigen processing-associated complex is essential for optimal peptide loading.Semantic proximity Read ↗

A Detailed Analysis of the Murine TAP Transporter Substrate SpecificitySemantic proximity Read ↗

The cell biology of major histocompatibility complex class I assembly: towards a molecular understandingSemantic proximity Read ↗

The Transporter Associated With Antigen Processing (TAP): Structural Integrity, Expression, Function, and Its Clinical RelevanceSemantic proximity Read ↗

Substrate selection by transporters associated with antigen processing occurs during peptide binding to TAP.Semantic proximity Read ↗

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Identifying MHC class I epitopes by predicting the TAP transport efficiency of epitope precursors.Semantic proximity Read ↗

Quantitative and Qualitative Influences of Tapasin on the Class I Peptide RepertoireSemantic proximity Read ↗

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