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Article

Structure and Dynamics of Antigenic Peptides in Complex with TAP

30 Jan 2017

Abstract excerpt

The transporter associated with antigen processing (TAP) selectively translocates antigenic peptides into the endoplasmic reticulum. Loading onto major histocompatibility complex class I molecules and proofreading of these bound epitopes are orchestrated within the macromolecular peptide-loading complex, which assembles on TAP. This heterodimeric ABC-binding cassette (ABC) transport complex is therefore a major...

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PMID: 28194151
DOI: 10.3389/fimmu.2017.00010

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