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Article

Principles of peptide selection by the transporter associated with antigen processing

28 May 2024

Abstract excerpt

Our ability to fight pathogens relies on major histocompatibility complex class I (MHC-I) molecules presenting diverse antigens on the surface of diseased cells. The transporter associated with antigen processing (TAP) transports nearly the entire repertoire of antigenic peptides into the endoplasmic reticulum for MHC-I loading. How TAP transports peptides specific for MHC-I is unclear. In this study, we used...

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PMID: 38805290
DOI: 10.1073/pnas.2320879121

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