[Analysis of genetic disorders of cancer of the rectum: differences in relation to cancer of the colon].

Article

[Analysis of genetic disorders of cancer of the rectum: differences in relation to cancer of the colon].

Gastroenterologie clinique et biologique - 1 Jan 2000

Rebischung C, Laurent-Puig P, Gerard J P, Thomas G, Hamelin R

Abstract excerpt

AIMS AND METHODS: We studied the mechanisms of colon and rectal carcinogenesis by analysing in a series of 83 rectal tumors the prevalence of the two tumor types characteristic of colon cancer, i.e., the LOH+ type, defined by p53 and APC mutations (studied by DGGE and protein truncation assay), a...

Topics

Aged
Colonic Neoplasms
Female
Genes, APC
Genes, p53
Genes, ras
Genotype
Humans
Loss of Heterozygosity
Male
Microsatellite Repeats
Middle Aged
Phenotype
Rectal Neoplasms

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