Article
[Analysis of genetic disorders of cancer of the rectum: differences in relation to cancer of the colon].
Gastroenterologie clinique et biologique - 1 Jan 2000
Rebischung C, Laurent-Puig P, Gerard J P, Thomas G, Hamelin R
Abstract excerpt
AIMS AND METHODS: We studied the mechanisms of colon and rectal carcinogenesis by analysing in a series of 83 rectal tumors the prevalence of the two tumor types characteristic of colon cancer, i.e., the LOH+ type, defined by p53 and APC mutations (studied by DGGE and protein truncation assay), and the RER+ type, which is characterized by the instability of some mononucleotide repeat microsatellites (Bat 25 and...
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