[Genetic alterations and molecular mechanisms underlying colorectal tumorigenesis].

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Article

[Genetic alterations and molecular mechanisms underlying colorectal tumorigenesis].

Minerva medica - 1 May 1998

Ronchetto F

Abstract excerpt

Tumor cells are cells that have acquired damage to genes that directly regulate their cell cycles. In the multistep process leading to colorectal carcinoma, the adenoma-carcinoma sequence is characterized by progressive accumulation of genetic abnormalities (K-ras oncogene mutation, allelic deletion on chromosome 5q, 18q, 17p). In a hereditary non-polyposis syndrome (Lynch syndrome II) and in about a quarter of...

Topics

Alleles
Apoptosis
Colorectal Neoplasms
Colorectal Neoplasms, Hereditary Nonpolyposis
DNA Repair
DNA, Satellite
Electrophoresis, Gel, Pulsed-Field
Genes, Tumor Suppressor
Genes, p53
Humans
Mutation
Polymorphism, Single-Stranded Conformational

Source

Open in PubMed

Identifiers

PMID: 9676181

Provenance

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