Article
Replication error phenotype, clinicopathological variables, and patient outcome in Dukes' B stage II (T3,N0,M0) colorectal cancer.
Gut - 1 Feb 2000
Curran B, Lenehan K, Mulcahy H, Tighe O, Bennett M A, Kay E W, O'Donoghue D P, Leader M, Croke D T
Abstract excerpt
AIMS: To examine the relation between the replication error (RER) phenotype and other genetic events, clinical features, and long term survival in patients with Dukes' B stage II (T3,N0,M0) colorectal cancer. METHODS: RER phenotype was investigated in 159 patients by PCR amplification of microsatellite marker loci on chromosomes 5q, 17p, 17q, and 18q from tumour DNA extracted from archival tissue. Data on...
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