Article
Hypermethylation of the p16 gene in sporadic T3N0M0 stage colorectal cancers: association with DNA replication error and shorter survival.
Oncology - 1 Jan 1999
Liang J T, Chang K J, Chen J C, Lee C C, Cheng Y M, Hsu H C, Wu M S, Wang S M, Lin J T, Cheng A L
Abstract excerpt
Hypermethylation in the promoter region of the p16 gene was suspected to be involved in the tumorigenesis of colorectal cancers, although its clinical and biological significance remains obscure. In this study, we collected 84 T3N0M0 stage primary colorectal cancers that were curatively resected. The clinicopathologic data were reviewed. p16 hypermethylation was determined by a methylation-specific polymerase...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.