A comparison of the genetic pathways involved in the pathogenesis of three types of colorectal cancer.

doi:10.1002/(SICI)1096-9896(199802)184:2<148::AID-PATH986>3.0.CO;2-M

Back to search

Article

A comparison of the genetic pathways involved in the pathogenesis of three types of colorectal cancer.

The Journal of pathology - 1 Feb 1998

Tomlinson I, Ilyas M, Johnson V, Davies A, Clark G, Talbot I, Bodmer W

Abstract excerpt

Patterns of allele loss (loss of heterozygosity, LOH) have been studied in order to investigate the genetic pathways involved in the pathogenesis of three types of colorectal cancer (CRC): sporadic CRC without replication errors (RER-) (32 cases); sporadic RER+ CRC (23 cases); and ulcerative coli...

Topics

Adult
Aged
Aged, 80 and over
Alleles
Cell Transformation, Neoplastic
Chromosome Deletion
Colitis, Ulcerative
Colorectal Neoplasms
Heterozygote
Humans
Microsatellite Repeats
Middle Aged
Polymerase Chain Reaction

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.