Article
Characterization of an apparent hotspot for spontaneous mutation in exon 5 of the Chinese hamster APRT gene.
Mutation research - 10 Jun 1996
Smith D G, Adair G M
Abstract excerpt
We describe an apparent hotspot for spontaneous deletions and base substitution mutations at a TTC trinucleotide direct repeat/MboII restriction site in exon 5 of the Chinese hamster APRT gene, in a region with the potential to form a relatively stable, quasipalindromic, stem-loop structure. The recurrent 3 bp TTC deletions observed at this site, which account for approx. 20% of the characterized spontaneous APRT...
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