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Article

Multiple dispersed spontaneous mutations: a novel pathway of mutation in a malignant human cell line.

Molecular and cellular biology - 1 Jun 1991

Harwood J, Tachibana A, Meuth M

Abstract excerpt

We analyzed the nature of spontaneous mutations at the autosomal locus coding for adenine phosphoribosyltransferase in the human colorectal carcinoma cell line SW620 to establish whether distinctive mutational pathways exist that might underlie the more complex genome rearrangements arising in tumor cells. Point mutations occur at a low rate in aprt hemizygotes derived from SW620, largely as a result of base...

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Identifiers

PMID: 2038324
DOI: 10.1128/mcb.11.6.3163-3170.1991
PMCID: PMC360167

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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