Article
Multiple dispersed spontaneous mutations: a novel pathway of mutation in a malignant human cell line.
Molecular and cellular biology - 1 Jun 1991
Harwood J, Tachibana A, Meuth M
Abstract excerpt
We analyzed the nature of spontaneous mutations at the autosomal locus coding for adenine phosphoribosyltransferase in the human colorectal carcinoma cell line SW620 to establish whether distinctive mutational pathways exist that might underlie the more complex genome rearrangements arising in tu...
Topics
- Adenine Phosphoribosyltransferase
- Adenocarcinoma
- Amino Acid Sequence
- Base Sequence
- Blotting, Southern
- Cell Line
- Chromosome Deletion
- Chromosomes, Human, Pair 16
- Colonic Neoplasms
- DNA, Neoplasm
- Frameshift Mutation
- Gene Rearrangement
- Humans
- Molecular Sequence Data
- Mutation
- Restriction Mapping