Article
A mutational hotspot in the aprt gene of Chinese hamster cells.
Mutation research - 1 Apr 1992
Belouchi A, Bradley W E
Abstract excerpt
Early work with adenine phosphoribosyltransferase-deficient mutants of CHO cells suggested that a site existed in the third exon of this gene which was preferentially susceptible to mutation by ethyl methanesulphonate. To determine whether this was real we analysed a large collection of induced mutants, and generated a high-density mutational spectrum for this exon. In addition, 4 sites outside exon 3 were...
Topics
- Adenine Phosphoribosyltransferase
- Animals
- Base Sequence
- CHO Cells
- Cricetinae
- Molecular Sequence Data
- Mutation