Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The nature of ultraviolet light-induced mutations at the heterozygous aprt locus in Chinese hamster ovary cells.

Mutation research - 1 Oct 1990

Drobetsky E A, Glickman B W

Abstract excerpt

A system for studying mutational specificity at a heterozygous locus in Chinese hamster ovary (CHO) cells is described. The strategy employed is based on restriction fragment analysis and DNA sequencing of enzymatically amplified mutant adenine phosphoribosyltransferase (aprt) alleles. We have demonstrated the usefulness of this approach through the characterization of a collection of aprt- mutants with respect...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Base Sequence
Share to Cell Line

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Heterozygote

Share to Molecular Sequence Data

Share to Mutation

Share to Polymerase Chain Reaction

Share to Polymorphism, Restriction Fragment Length

Source

Identifiers

PMID: 1977078
DOI: 10.1016/0027-5107(90)90135-q

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The nature of ultraviolet light-induced mutations at the heterozygous aprt locus in Chinese hamster ovary cells.PMID 1977078Read ↗

Loss of heterozygosity in mammalian cell mutagenesis: molecular analysis of spontaneous mutations at the aprt locus in CHO cells.Semantic proximity Read ↗

Determination of spontaneous loss of heterozygosity mutations in Aprt heterozygous mice.Semantic proximity Read ↗

Loss of heterozygosity: the most frequent cause of recessive phenotype expression at the heterozygous human adenine phosphoribosyltransferase locus.Semantic proximity Read ↗

Molecular bases for hereditary cancer-prone diseases.Semantic proximity Read ↗

Characterization of an apparent hotspot for spontaneous mutation in exon 5 of the Chinese hamster APRT gene.Semantic proximity Read ↗

A mutational hotspot in the aprt gene of Chinese hamster cells.Semantic proximity Read ↗

Reduction to homozygosity is the predominant spontaneous mutational event in cultured human lymphoblastoid cells.Semantic proximity Read ↗

The mutational specificity of simulated sunlight at the aprt locus in rodent cells.Semantic proximity Read ↗

APRT: a versatile in vivo resident reporter of local mutation and loss of heterozygosity.Semantic proximity Read ↗

A novel signature mutation for oxidative damage resembles a mutational pattern found commonly in human cancers.Semantic proximity Read ↗

Intervention of somatic mutational events in vivo by a germline defect at the adenine phosphoribosyltransferase locus.Semantic proximity Read ↗

Allelic losses in mutations at the aprt locus of human lymphoblastoid cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.