The nature of ultraviolet light-induced mutations at the heterozygous aprt locus in Chinese hamster ovary cells.

doi:10.1016/0027-5107(90)90135-q

Back to search

Article

The nature of ultraviolet light-induced mutations at the heterozygous aprt locus in Chinese hamster ovary cells.

Mutation research - 1 Oct 1990

Drobetsky E A, Glickman B W

Abstract excerpt

A system for studying mutational specificity at a heterozygous locus in Chinese hamster ovary (CHO) cells is described. The strategy employed is based on restriction fragment analysis and DNA sequencing of enzymatically amplified mutant adenine phosphoribosyltransferase (aprt) alleles. We have de...

Topics

Adenine Phosphoribosyltransferase
Alleles
Animals
Base Sequence
Cell Line
Heterozygote
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Ultraviolet Rays

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.