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Article

Two genes abrogate the inhibition of murine hepatocarcinogenesis by ovarian hormones.

Proceedings of the National Academy of Sciences of the United States of America - 11 Jun 1996

Poole T M, Drinkwater N R

Abstract excerpt

Hormonal and genetic factors strongly influence the susceptibility of inbred mice to hepatocarcinogenesis. Female C57BR/cdJ (BR) mice are extremely susceptible to liver tumor induction relative to other strains because they are genetically insensitive to the inhibition of hepatocarcinogenesis by ovarian hormones. To determine the genetic basis for the sensitivity of BR mice relative to resistant C57BL/6J (B6)...

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Identifiers

PMID: 8650181
DOI: 10.1073/pnas.93.12.5848
PMCID: PMC39150

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