Article
Mice heterozygous for a Brca1 or Brca2 mutation display distinct mammary gland and ovarian phenotypes in response to diethylstilbestrol.
Cancer research - 1 Jul 2000
Bennett L M, McAllister K A, Malphurs J, Ward T, Collins N K, Seely J C, Gowen L C, Koller B H, Davis B J, Wiseman R W
Abstract excerpt
Women who inherit mutations in the breast cancer susceptibility genes, BRCA1 and BRCA2, are predisposed to the development of breast and ovarian cancer. We used mice with a Brca1 mutation on a BALB/cJ inbred background (BALB/cB1+/- mice) or a Brca2 genetic alteration on the 129/SvEv genetic background (129B2+/- mice) to investigate potential gene-environment interactions between defects in these genes and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.