Article
Resistance of DRH strain rats to chemical carcinogenesis of liver: genetic analysis of later progression stage.
Carcinogenesis - 1 Jan 2002
Yan Ying, Zeng Zhao-Zhu, Higashi Shin, Denda Ayumi, Konishi Yoichi, Onishi Shunzo, Ueno Hikaru, Higashi Ken, Hiai Hiroshi
Abstract excerpt
The inbred DRH rats are highly resistant to the induction of hepatocellular carcinoma (HCC) by feeding of 3'-methyl-4-dimethylaminoazobenzene (3'-Me-DAB). Previously, we found that two quantitative trait loci (QTLs), Drh1 and Drh2, significantly reduced the number, size and area of glutathione S-transferase-placental form (GST-P)-positive foci and GST-P mRNA levels in (F344xDRH)F(2) rat livers induced by feeding...
Topics
- Animals
- Carcinoma, Hepatocellular
- Chromosome Mapping
- Crosses, Genetic
- Disease Progression
- Female
- Genetic Predisposition to Disease
- Genotype
- Glutathione Transferase
- Liver Neoplasms, Experimental
- Lod Score
- Male
- Methyldimethylaminoazobenzene