Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mapping a sex hormone-sensitive gene determining female resistance to liver carcinogenesis in a congenic F344.BN-Hcs4 rat.

Cancer research - 1 Nov 2006

De Miglio Maria R, Virdis Patrizia, Calvisi Diego F, Frau Maddalena, Muroni Maria R, Simile Maria M, Daino Lucia, Careddu Giovanni M, Sanna-Passino Eraldo, Pascale Rosa M, Feo Francesco

Abstract excerpt

Hepatocellular carcinoma (HCC) is prevalent in human and rodent males. Hepatocarcinogenesis is controlled by various genes in susceptible F344 and resistant Brown Norway (BN) rats. B alleles at Hcs4 locus, on RNO16, control neoplastic nodule volume. We constructed the F344.BN-Hcs4 recombinant congenic strain (RCS) by introgressing a 4.41-cM portion of Hcs4 from BN strain in an isogenic F344 background....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Estrogen Receptor alpha
Share to Gonadal Steroid Hormones

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Liver Neoplasms, Experimental

Share to Rats, Inbred BN

Share to Rats, Inbred F344

Share to Receptors, Androgen

Share to Recombination, Genetic

Share to Sex Factors

Source

Identifiers

PMID: 17079458
DOI: 10.1158/0008-5472.CAN-06-2881

Genes

PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mapping a sex hormone-sensitive gene determining female resistance to liver carcinogenesis in a congenic F344.BN-Hcs4 rat.PMID 17079458Read ↗

The BN rat strain carries dominant hepatocarcinogen resistance loci.Semantic proximity Read ↗

Chromosome mapping of multiple loci affecting the genetic predisposition to rat liver carcinogenesis.Semantic proximity Read ↗

Hepatocellular carcinoma as a complex polygenic disease. Interpretive analysis of recent developments on genetic predisposition.Semantic proximity Read ↗

Predominant modifier of extreme liver cancer susceptibility in C57BR/cdJ female mice localized to 6 Mb on chromosome 17.Semantic proximity Read ↗

Identification of genetic loci controlling hepatocarcinogenesis on rat chromosomes 7 and 10.Semantic proximity Read ↗

Hepatocarcinogenesis in BXH recombinant inbred strains of mice: analysis of diverse phenotypic effects of the hepatocarcinogen sensitivity loci.Semantic proximity Read ↗

Phenotypic reversion of rat neoplastic liver nodules is under genetic control.Semantic proximity Read ↗

Genetic and epigenetic control of molecular alterations in hepatocellular carcinoma.Semantic proximity Read ↗

Two genes abrogate the inhibition of murine hepatocarcinogenesis by ovarian hormones.Semantic proximity Read ↗

Genetic control of resistance to hepatocarcinogenesis by the mouse Hpcr3 locus.Semantic proximity Read ↗

Polygenic control of hepatocarcinogenesis in Copenhagen x F344 rats.Semantic proximity Read ↗

Genetic resistance to chemical carcinogen-induced preneoplastic hepatic lesions in DRH strain rats.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.