Chromosome mapping of multiple loci affecting the genetic predisposition to rat liver carcinogenesis.

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Chromosome mapping of multiple loci affecting the genetic predisposition to rat liver carcinogenesis.

Cancer research - 1 Aug 2002

De Miglio Maria R, Pascale Rosa M, Simile Maria M, Muroni Maria R, Calvisi Diego F, Virdis Patrizia, Bosinco Giovanni M, Frau Maddalena, Seddaiu Maria A, Ladu Sara, Feo Francesco

Abstract excerpt

Previous studies on (BNxF344)F1 (BFF1) rat model of genetic predisposition to hepatocarcinogenesis led to the identification, in BFF1xF344 backcross progeny, of two hepatocarcinogenesis susceptibility (Hcs) and three resistance (Hcr) loci affecting the progression of neoplastic liver nodules. To evaluate the presence of other hepatocarcinogenesis-related loci in the BFF1 genome, nodule induction by resistant...

Topics

Animals
Carcinogens
Chromosome Mapping
Crosses, Genetic
Diethylnitrosamine
Female
Genetic Linkage
Genetic Predisposition to Disease
Liver Neoplasms, Experimental
Male
Quantitative Trait, Heritable
Rats
Rats, Inbred BN

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Rats, Inbred F344

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PMID: 12154055

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