Germ-line inactivation of the murine Eck receptor tyrosine kinase by gene trap retroviral insertion.

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Article

Germ-line inactivation of the murine Eck receptor tyrosine kinase by gene trap retroviral insertion.

Oncogene - 7 Mar 1996

Chen J, Nachabah A, Scherer C, Ganju P, Reith A, Bronson R, Ruley H E

Abstract excerpt

The present study characterized a mutation in the Eck receptor tyrosine kinase gene induced by the U3betageo gene trap retrovirus. The mutation (eck(i)) was identified during an in vitro screen for proviruses that disrupt developmentally regulated genes in cultured ES cells. The germ-line eck(i)...

Topics

Animals
Base Sequence
Blastocyst
Exons
Female
Genes
Genetic Vectors
Homozygote
Male
Membrane Proteins
Mice
Mice, Inbred C57BL
Molecular Sequence Data
Mutagenesis, Insertional
Phenotype
Proviruses
Receptor Protein-Tyrosine Kinases
Receptor, EphA2

Source

Open in PubMed

Identifiers

PMID: 8649815

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8649815-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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