Article
Germ-line inactivation of the murine Eck receptor tyrosine kinase by gene trap retroviral insertion.
Oncogene - 7 Mar 1996
Chen J, Nachabah A, Scherer C, Ganju P, Reith A, Bronson R, Ruley H E
Abstract excerpt
The present study characterized a mutation in the Eck receptor tyrosine kinase gene induced by the U3betageo gene trap retrovirus. The mutation (eck(i)) was identified during an in vitro screen for proviruses that disrupt developmentally regulated genes in cultured ES cells. The germ-line eck(i) fusion gene was expressed in blastocyst and later restricted to the primitive streak, node and to regions of the...
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