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Article

Knockouts of Kekkon1 define sequence elements essential for Drosophila epidermal growth factor receptor inhibition.

Genetics - 1 Jan 2004

Alvarado Diego, Rice Amy H, Duffy Joseph B

Abstract excerpt

Throughout development, cells utilize feedback inhibition of receptor tyrosine kinase (RTK) signaling as an important means to direct cellular fates. In Drosophila, epidermal growth factor receptor (EGFR) activity is tightly regulated by a complex array of autoregulatory loops, involving an assortment of inhibitory proteins. One inhibitor, the transmembrane protein Kekkon1 (Kek1) functions during oogenesis in a...

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Identifiers

PMID: 15020418
DOI: 10.1534/genetics.166.1.201
PMCID: PMC1470717

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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