Article
Mice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and inner ear.
Development (Cambridge, England) - 1 Jan 1993
Mansour S L, Goddard J M, Capecchi M R
Abstract excerpt
We derived mice that carry a targeted insertion of a neor gene in the int-2 (Fgf-3) proto-oncogene coding sequences. The mutation was found to be recessive and mice that were homozygous for the insertion did not often survive to adulthood. The mutant mice had defects in the development of the tai...
Topics
- Animals
- Blotting, Southern
- Ear, Inner
- Genes, Recessive
- Homozygote
- Mice
- Mice, Mutant Strains
- Mutagenesis, Insertional
- Phenotype
- Polymerase Chain Reaction
- Protein-Tyrosine Kinases
- Proto-Oncogene Mas