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Article

The Evi1 proto-oncogene is required at midgestation for neural, heart, and paraxial mesenchyme development.

Mechanisms of development - 1 Jul 1997

Hoyt P R, Bartholomew C, Davis A J, Yutzey K, Gamer L W, Potter S S, Ihle J N, Mucenski M L

Abstract excerpt

The ecotropic viral integration site-1 (Evi1) locus was initially identified as a common site of retroviral integration in myeloid tumors of the AKXD-23 recombinant inbred mouse strain. The full-length Evi1 transcript encodes a putative transcription factor, containing ten zinc finger motifs found within two domains of the protein. To determine the biological function of the Evi1 proto-oncogene, the full-length,...

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Identifiers

PMID: 9256345
DOI: 10.1016/s0925-4773(97)00057-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Evi1 proto-oncogene is required at midgestation for neural, heart, and paraxial mesenchyme development.PMID 9256345Read ↗

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The Zinc Finger SET Domain Gene Prdm14 Is Overexpressed in Lymphoblastic Lymphomas with Retroviral Insertions at Evi32Semantic proximity Read ↗

Evi‐1 promotes para‐aortic splanchnopleural hematopoiesis through up‐regulation of GATA‐2 and repression of TGF‐b signalingSemantic proximity Read ↗

EVI1 drives leukemogenesis through aberrant ERG activationSemantic proximity Read ↗

Mouse models in the study of the Ets family of transcription factors.Semantic proximity Read ↗

Point Mutations in Two EVI1 Zn Fingers Abolish EVI1-GATA1 Interaction and Allow Erythroid Differentiation of Murine Bone Marrow CellsSemantic proximity Read ↗

<i>Evi9</i> Encodes a Novel Zinc Finger Protein That Physically Interacts with BCL6, a Known Human B-Cell Proto-Oncogene ProductSemantic proximity Read ↗

Erythroid defects and increased retrovirally-induced tumor formation in Evi1 transgenic mice.Semantic proximity Read ↗

Evi1 is essential for hematopoietic stem cell self-renewal, and its expression marks hematopoietic cells with long-term multilineage repopulating activity.Semantic proximity Read ↗

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