Article
The Evi1 proto-oncogene is required at midgestation for neural, heart, and paraxial mesenchyme development.
Mechanisms of development - 1 Jul 1997
Hoyt P R, Bartholomew C, Davis A J, Yutzey K, Gamer L W, Potter S S, Ihle J N, Mucenski M L
Abstract excerpt
The ecotropic viral integration site-1 (Evi1) locus was initially identified as a common site of retroviral integration in myeloid tumors of the AKXD-23 recombinant inbred mouse strain. The full-length Evi1 transcript encodes a putative transcription factor, containing ten zinc finger motifs foun...
Topics
- Animals
- DNA-Binding Proteins
- Embryonic and Fetal Development
- Female
- Gene Expression Regulation, Developmental
- Heart
- In Situ Hybridization
- MDS1 and EVI1 Complex Locus Protein
- Mesoderm
- Mice
- Mutation
- Neural Crest
- Pregnancy
- Proto-Oncogenes
- Transcription Factors