Article
Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects.
PloS one - 1 Jan 2014
Bard-Chapeau Emilie A, Szumska Dorota, Jacob Bindya, Chua Belinda Q L, Chatterjee Gouri C, Zhang Yi, Ward Jerrold M, Urun Fatma, Kinameri Emi, Vincent Stéphane D, Ahmed Sayadi, Bhattacharya Shoumo, Osato Motomi, Perkins Archibald S, Moore Adrian W, Jenkins Nancy A, Copeland Neal G
Abstract excerpt
The ecotropic viral integration site 1 (Evi1) oncogenic transcription factor is one of a number of alternative transcripts encoded by the Mds1 and Evi1 complex locus (Mecom). Overexpression of Evi1 has been observed in a number of myeloid disorders and is associated with poor patient survival. It is also amplified and/or overexpressed in many epithelial cancers including nasopharyngeal carcinoma, ovarian...
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