Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Affinity maturation and hypermutation in a simulation of the humoral immune response.

European journal of immunology - 1 Jun 1996

Celada F, Seiden P E

Abstract excerpt

By experimenting with a cellular automaton model of the immune system, we have reproduced affinity maturation of the antibody response, a somatic adaptation to a changing environment. The simulation allowed the isolation of a number of variables, e.g. the fraction of repertoire available, the mag...

Topics

Antibody Affinity
Antibody Formation
B-Lymphocytes
Computer Simulation
Genes, Immunoglobulin
Lymphocyte Cooperation
Models, Biological
Mutation

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 8647216
DOI: 10.1002/eji.1830260626

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8647216-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Affinity maturation and hypermutation in a simulation of the humoral immune response.PMID 8647216Read ↗

Somatic mutation, affinity maturation and the antibody repertoire: a computer model.Semantic proximity Read ↗

Somatic evolution in the immune system: the need for germinal centers for efficient affinity maturation.Semantic proximity Read ↗

Regulated somatic hypermutation enhances antibody affinity maturationSemantic proximity Read ↗

Maturation of the humoral immune response as an optimization problem.Semantic proximity Read ↗

Multiscale affinity maturation simulations to elicit broadly neutralizing antibodies against HIVSemantic proximity Read ↗

Limits for Antibody Affinity Maturation and Repertoire Diversification in Hypervaccinated HumansSemantic proximity Read ↗

Reconciling repertoire shift with affinity maturation: the role of deleterious mutations.Semantic proximity Read ↗

Somatic hypermutation in B cells: an optimal control treatment.Semantic proximity Read ↗

Optimality of mutation and selection in germinal centers.Semantic proximity Read ↗

Affinity maturation and class switching.Semantic proximity Read ↗

Affinity selection and repertoire shift: paradoxes as a consequence of somatic mutation?Semantic proximity Read ↗

Affinity maturation of B cells involves not only a few but a whole spectrum of relevant mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.