Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Somatic evolution in the immune system: the need for germinal centers for efficient affinity maturation.

Journal of theoretical biology - 21 May 1997

Pierre D M, Goldman D, Bar-Yam Y, Perelson A S

Abstract excerpt

In the course of a humoral immune response, the average affinity of antibody for the immunizing antigen can increase in time. This process of affinity maturation is due to antigen-driven selection of higher affinity B cell clones and somatic hypermutation of the genes that code for the antibody variable region. Through the use of simulation models we show that the efficiency of affinity maturation is...

Topics

Antibody Affinity
Antibody Formation
B-Lymphocytes
Humans
Immunity, Cellular
Lymphoid Tissue
Models, Immunological
Mutation
Time Factors

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 9196657
DOI: 10.1006/jtbi.1996.0350

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-9196657-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Somatic evolution in the immune system: the need for germinal centers for efficient affinity maturation.PMID 9196657Read ↗

Regulated somatic hypermutation enhances antibody affinity maturationSemantic proximity Read ↗

Optimality of mutation and selection in germinal centers.Semantic proximity Read ↗

Continuous germinal center invasion contributes to the diversity of the immune responseSemantic proximity Read ↗

Somatic hypermutation in B cells: an optimal control treatment.Semantic proximity Read ↗

Computational Model Reveals a Stochastic Mechanism behind Germinal Center Clonal BurstsSemantic proximity Read ↗

Somatic mutation, affinity maturation and the antibody repertoire: a computer model.Semantic proximity Read ↗

Cyclic re-entry of germinal center B cells and the efficiency of affinity maturation.Semantic proximity Read ↗

Reconciling repertoire shift with affinity maturation: the role of deleterious mutations.Semantic proximity Read ↗

Affinity selection and repertoire shift: paradoxes as a consequence of somatic mutation?Semantic proximity Read ↗

Replaying germinal center evolution on a quantified affinity landscapeSemantic proximity Read ↗

System-Level Scenarios for the Elucidation of T Cell-Mediated Germinal Center B Cell Differentiation.Semantic proximity Read ↗

Affinity‐based selection and the germinal center responseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.