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Article

Reconciling repertoire shift with affinity maturation: the role of deleterious mutations.

Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 1999

Shannon M, Mehr R

Abstract excerpt

The shift in Ab repertoire, from Abs dominating certain primary B cell responses to genetically unrelated Abs dominating subsequent "memory" responses, challenges the accepted paradigm of affinity maturation. We used mathematical modeling and computer simulations of the dynamics of B cell responses, hypermutation, selection, and memory cell formation to test hypotheses attempting to explain repertoire shift. We...

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PMID: 10201914

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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