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Article

Optimality of mutation and selection in germinal centers.

PLoS computational biology - 3 Jun 2010

Zhang Jingshan, Shakhnovich Eugene I

Abstract excerpt

The population dynamics theory of B cells in a typical germinal center could play an important role in revealing how affinity maturation is achieved. However, the existing models encountered some conflicts with experiments. To resolve these conflicts, we present a coarse-grained model to calculate the B cell population development in affinity maturation, which allows a comprehensive analysis of its parameter...

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Identifiers

PMID: 20532164
DOI: 10.1371/journal.pcbi.1000800
PMCID: PMC2880589

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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