Affinity maturation and class switching.

doi:10.1016/s0952-7915(96)80110-5

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Article

Affinity maturation and class switching.

Current opinion in immunology - 1 Feb 1996

Wabl M, Steinberg C

Abstract excerpt

Affinity maturation and class switching of antibodies are temporally, but not mechanistically, related processes. The basis of affinity maturation is the selection, in the germinal centers, of antibodies that bind the antigen better. Early in an immune response, the selection is from the primary...

Topics

Animals
Antibody Affinity
DNA-Binding Proteins
Genes, Immunoglobulin
Homeodomain Proteins
Humans
Immunoglobulin Class Switching
Immunoglobulin Variable Region
Mice
Mutation
Nuclear Proteins
Proteins

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