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Article

Affinity maturation and class switching.

Current opinion in immunology - 1 Feb 1996

Wabl M, Steinberg C

Abstract excerpt

Affinity maturation and class switching of antibodies are temporally, but not mechanistically, related processes. The basis of affinity maturation is the selection, in the germinal centers, of antibodies that bind the antigen better. Early in an immune response, the selection is from the primary repertoire; later, it is from mutants generated by hypermutation at the immunoglobulin loci. Recently, the door has...

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Identifiers

PMID: 8729451
DOI: 10.1016/s0952-7915(96)80110-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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