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Article

Somatic hypermutation in B cells: an optimal control treatment.

Journal of theoretical biology - 7 Sept 1993

Kepler T B, Perelson A S

Abstract excerpt

The vertebrate immune system generates high-affinity antibodies to external antigens through a process of somatic hypermutation that takes place in germinal centers formed in the secondary lymphoid tissues. B cells proliferating in these germinal centers experience random mutations in the genes encoding the variable region of their immunoglobulin molecules and are subsequently selected for high-affinity binding...

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Source

Identifiers

PMID: 8264243
DOI: 10.1006/jtbi.1993.1139

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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