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Article

Somatic hypermutation in B cells: an optimal control treatment.

Journal of theoretical biology - 7 Sept 1993

Kepler T B, Perelson A S

Abstract excerpt

The vertebrate immune system generates high-affinity antibodies to external antigens through a process of somatic hypermutation that takes place in germinal centers formed in the secondary lymphoid tissues. B cells proliferating in these germinal centers experience random mutations in the genes e...

Topics

Animals
Antibody Affinity
Antigens
B-Lymphocytes
Cell Division
Immunoglobulin Variable Region
Kinetics
Lymphocyte Activation
Mathematics
Models, Genetic
Mutation
Vertebrates

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Identifiers

PMID: 8264243
DOI: 10.1006/jtbi.1993.1139

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8264243-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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