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Article

Affinity selection and repertoire shift: paradoxes as a consequence of somatic mutation?

Immunological reviews - 1 Apr 1998

Andersson K, Wrammert J, Leanderson T

Abstract excerpt

Affinity selection of antibodies during immune responses relies on two mechanisms, one molecular that involves the targeted introduction of somatic mutations into rearranged immunoglobulin genes and one cellular that involves the clonal expansion of B cells expressing a surface immunoglobulin with a higher affinity for antigen compared to their competitors. In this review we focus on the conditions for affinity...

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Source

Identifiers

PMID: 9602363
DOI: 10.1111/j.1600-065x.1998.tb01440.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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