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Article

Affinity selection and repertoire shift: paradoxes as a consequence of somatic mutation?

Immunological reviews - 1 Apr 1998

Andersson K, Wrammert J, Leanderson T

Abstract excerpt

Affinity selection of antibodies during immune responses relies on two mechanisms, one molecular that involves the targeted introduction of somatic mutations into rearranged immunoglobulin genes and one cellular that involves the clonal expansion of B cells expressing a surface immunoglobulin wit...

Topics

Animals
Antibody Diversity
Antibody Specificity
Antigen-Antibody Complex
Genes, Immunoglobulin
Humans
Immunologic Memory
Models, Genetic
Mutation

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 9602363
DOI: 10.1111/j.1600-065x.1998.tb01440.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9602363-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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