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Limits for Antibody Affinity Maturation and Repertoire Diversification in Hypervaccinated Humans

20 Sept 2011

Abstract excerpt

The immune system is known to generate a diverse panel of high-affinity Abs by adaptively improving the recognition of pathogens during ongoing immune responses. In this study, we report the biological limits for Ag-driven affinity maturation and repertoire diversification by analyzing Ab repertoires in two adult volunteers after each of three consecutive booster vaccinations with tetanus toxoid. Maturation of...

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PMID: 21930965
DOI: 10.4049/jimmunol.1000928

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