Article
Modulation of promiscuous T cell receptor recognition by mutagenesis of CDR2 residues.
The Journal of experimental medicine - 1 May 1996
Brawley J V, Concannon P
Abstract excerpt
The T cell receptor (TCR) recognizes a ligand composed of a major histocompatibility complex (MHC) molecule and a peptide antigen. Prior studies of murine T cell clones have demonstrated that residues in the CDR3 region of TCR interact with amino acids in the peptide during MHC-restricted antigen...
Topics
- Alleles
- Amino Acid Sequence
- Cell Line
- Clone Cells
- Epitopes
- HLA-DR Antigens
- Humans
- Influenza A virus
- Major Histocompatibility Complex
- Molecular Sequence Data
- Receptor-CD3 Complex, Antigen, T-Cell
- Receptors, Antigen, T-Cell
- Recombinant Proteins
- T-Lymphocytes
- Transfection
- Tumor Cells, Cultured