Article
Structural basis of specificity and degeneracy of T cell recognition: pluriallelic restriction of T cell responses to a peptide antigen involves both specific and promiscuous interactions between the T cell receptor, peptide, and HLA-DR.
Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 1998
Doherty D G, Penzotti J E, Koelle D M, Kwok W W, Lybrand T P, Masewicz S, Nepom G T
Abstract excerpt
TCR engagement of peptide-MHC class II ligands involves specific contacts between the TCR and residues on both the MHC and peptide molecules. We have used molecular modeling and assays of peptide binding and T cell function to characterize these interactions for a CD4+ Th1 cell clone, ESL4.34, wh...
Topics
- Alleles
- Amino Acid Sequence
- Antigen Presentation
- Clone Cells
- Cytotoxicity, Immunologic
- Epitopes, T-Lymphocyte
- HLA-DR Antigens
- Herpes Simplex Virus Protein Vmw65
- Herpesvirus 2, Human
- Humans
- Molecular Sequence Data
- Peptide Fragments
- Protein Binding