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Article

Structural basis for enabling T-cell receptor diversity within biased virus-specific CD8+ T-cell responses.

Proceedings of the National Academy of Sciences of the United States of America - 7 Jun 2011

Day E Bridie, Guillonneau Carole, Gras Stephanie, La Gruta Nicole L, Vignali Dario A A, Doherty Peter C, Purcell Anthony W, Rossjohn Jamie, Turner Stephen J

Abstract excerpt

Pathogen-specific responses are characterized by preferred profiles of peptide+class I MHC (pMHCI) glycoprotein-specific T-cell receptor (TCR) Variable (V)-region use. How TCRV-region bias impacts TCRαβ heterodimer selection and resultant diversity is unclear. The D(b)PA(224)-specific TCR repertoire in influenza A virus-infected C57BL/6J (B6) mice exhibits a preferred TCRV-region bias toward the TRBV29 gene...

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Share to CD8-Positive T-Lymphocytes
Share to Complementarity Determining Regions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Influenza A Virus, H3N2 Subtype

Share to Orthomyxoviridae Infections

Share to Protein Multimerization

Share to Protein Structure, Secondary

Share to Receptors, Antigen, T-Cell

Share to Receptors, Antigen, T-Cell, alpha-beta

Source

Open in PubMed Open full text

Identifiers

PMID: 21606376
DOI: 10.1073/pnas.1106851108
PMCID: PMC3111262

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Structural basis for enabling T-cell receptor diversity within biased virus-specific CD8+ T-cell responses.PMID 21606376Read ↗

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