Article
Microvariation creates significant functional differences in the DR3 molecules.
Human immunology - 1 Jan 1995
Posch P E, Araujo H A, Creswell K, Praud C, Johnson A H, Hurley C K
Abstract excerpt
Two DR3 molecules differ by four amino acids whose side chains point into the DR antigen-binding groove. To begin to assess the role of microvariation on DR3 function, DRB1*0302 residues were replaced with DRB1*0301 residues at beta-chain positions 26, 47, 86, and 47 plus 86. Murine fibroblast ce...
Topics
- Amino Acid Sequence
- Amino Acids
- Animals
- Antibodies, Monoclonal
- Antigen Presentation
- Cell Line
- DNA, Complementary
- Fibroblasts
- Genetic Variation
- HLA-DR Antigens
- HLA-DR3 Antigen
- HLA-DRB1 Chains
- Hemagglutinin Glycoproteins, Influenza Virus
- Hemagglutinins, Viral
- Humans
- Mice
- Models, Molecular
- Molecular Sequence Data