Article
Microvariation creates significant functional differences in the DR3 molecules.
Human immunology - 1 Jan 1995
Posch P E, Araujo H A, Creswell K, Praud C, Johnson A H, Hurley C K
Abstract excerpt
Two DR3 molecules differ by four amino acids whose side chains point into the DR antigen-binding groove. To begin to assess the role of microvariation on DR3 function, DRB1*0302 residues were replaced with DRB1*0301 residues at beta-chain positions 26, 47, 86, and 47 plus 86. Murine fibroblast cell lines expressing DR(alpha, beta 1*0301), DR(alpha, beta 1*0302), and the four mutant 0302 molecules were examined...
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