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Article

Fine-tuning of T-cell receptor avidity to increase HIV epitope variant recognition by cytotoxic T lymphocytes.

AIDS (London, England) - 13 Nov 2010

Bennett Michael S, Joseph Aviva, Ng Hwee L, Goldstein Harris, Yang Otto O

Abstract excerpt

OBJECTIVE: T-cell receptor (TCR) gene therapy is an approach being considered for HIV-1, but epitope mutation is a significant barrier. We assessed whether HIV-specific TCR can be modified to have broader coverage of epitope variants by recombining polymorphisms between public clonotype TCR sequences. DESIGN: Public clonotype TCRs recognizing the same epitope often differ by polymorphisms in their third...

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Share to Cytotoxicity Tests, Immunologic
Share to Epitopes, T-Lymphocyte

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to gag Gene Products, Human Immunodeficiency Virus

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Share to Receptors, Antigen, T-Cell

Share to T-Lymphocytes, Cytotoxic

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Source

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Identifiers

PMID: 20881472
DOI: 10.1097/QAD.0b013e32833f7b22
PMCID: PMC2997528

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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